Cell Metabolism and Signaling

Under this research line, namely Cell Metabolism and Signaling, we will be focused on the realization of a 3D co-cultured tumor model to shed light on the different stages of cancer initiation, growth and progression. The research will investigate the different aspects of the tumor microenvironment as the cell-cell and cell-ECM interaction, hypoxia, angiogenesis and the changing in the tumor metabolism, highlighting the molecular mechanisms driving the crosstalk among the cells involved in cancer progression as cancer cells, fibroblasts, endothelial cells and immune system cells.